Prednisone is our first candidate to top the list of the most side effective medications.
Prednisone is in a class of medications called corticosteroids. It is used to treat low levels of corticosteroids by replacing steroids that are produced naturally by the body. It is used to treat other conditions by reducing swelling and redness and by changing the way the immune system works.
Weight increase, moodiness and insomnia are the top side effects associated with Prednisone and all of them with the X-factor > 2, that is occurring at least twice as often in prednisone reviews than in the entire database of patient reviews.
Accoriding to http://www.sideeffective.com/drug/prednisone/, here are the top side effects for prednisone and frequencies of their occurrence in the entire body of patient reviews for prednisone:
weight increase 753 9.05%
moodiness 367 4.41%
insomnia 344 4.13%
depression 198 2.38%
anxiety 183 2.20%