No, it’s not that X-factor with Simon Cowell! Our own X-factor tells us how much more often a side effect is likely to occur for a medication in comparison to the frequency in the whole body of all patient reviews. For example, an X-factor of 3.45x means that the side effect is 3.45 more likely to occur for a given drug (than in the entire population of several hundred thousands of reviews which we have in our database).
Most people do not want to gain weight. Eating less is probably a good idea. Unfortunately, some drugs may carry the weight increase as a “heavy” price tag for their usage.
What are the highest X-factor medications for weight gain?
Antidepressants, antipsychotic and anti seizure medications dominate that list . However, all are beaten to the finish line by a ….female hormone. It is Depo-provera that “boasts” the highest X-factor from them all with the whopping 5x! The runner ups include Zyprexa with 4.84x and Remeron (popular antdepressant) with 3.63x. Zoloft, the front runner among antidepressants in terms of popularity, pales in comparison having the X-factor of 0.95. Thus it is *less* likely to gain weight as a side effect with Zoloft than of any random medication. So, if switching from Zoloft to Remeron helps your depression that’s great – but be prepared for extra pounds….